THIS IS A COMPREHENSIVE EXAM
- Stress, Pleasure & Addiction
- Stress
- Perception, Coping, Modulation
- Importance of prediction and control
- Prediction is only helpful if you can control the situation (medium level stress with time to change = good if you can predict)
- Control is good is you can control it but not good if you think you have control but you really don't
- Pleasure
- Brain (pleasure pathway), Stress
- Limbic System
- Ventral Tegmentum goes from limbic system to the prefrontal cortex
- Think of the main parts of the Triune brain (the pleasure pathway cuts across all of that)
- Addiction
- Dopamine, stress
- Addiction chances are much higher if you are stressed out
- If you eat junk food when stressed then it maximizes the pleasure of the food (emotional eating)
- Dopamine is the key neurotransmitter in the pleasure pathway
- Adrenaline junkies should really be called?
- Glucocorticoid Junkies or Cortisol Junkies
- Stress & Placebo
- Placebo
- Define
- Something that is not real but you get a physiological response based on perception
- Pathways
- The pleasure pathway is involved with dopamine playing a key role
- Effects (centrally mediated)
- Parkinson's as a Powerful Case
- This is where you have too little dopamine
- Placebo's given to these patients show an increase in dopamine
- Placebo Surgery
- Stress & Placebo
- Stress key in placebo (as is emotion)
- Stress management helps us harness power of placebo
- If they perceive less stress they perceive less pain
- Stress & Depression
- Depression is stress
- Radical statement
- the same physiology between depression and stress response
- Unipolar depression increasing rapidly
- One of the key factors of unipolar depressions is that stress is a predictor of your first major depressive episode
- Biology of depression
- Neurotransmitters
- Seratonin
- Dopamine
- Norepinephrine: behavior and activity
- Brain Regions
- Limbic system
- Hippocampus (shrinks in depression)
- Prefrontal cortex (shrinks in depression)
- Role of cortisol (glucocorticoids)
- Cortisol is very high
- Metabolic hormone (higher in the morning, lowest at night)
- For depressive patients their nighttime cortisol is elevated
- They are looking at ways to reduce cortisol to reduce depression
- Stress
- Anti-depressants-placebo
- If you have mild to moderate depression
- Interventions (exercise)
- This helps anti depression about as much as zoloft which is a common anti depressant
- Stress Theory (psychodynamics, learned helplessness)
- The common underlying aspect of depression is stress
- Stress integrates theories
- Stress, Anxiety, & Hostility
- Personality
- We differ in support, control, and coping
- Stress prone personalities tend to over respond to stress & don't use coping resources
- Anxiety
- Define
- Constant vigilance for threat, anticipate the worst
- Too much sympathetic activation (norepi, epi)
- There is a high correlation between depression and anxiety but here the focus is norepi and epi instead of cortisol
- Impacts hippocampus and amygdala
- Hostility
- Type A
- Hard driving business person
- Hostility is the key component of type A
- Synically hostile person who see's others as challenging or threatening
- It is circular because this type of personality pulls out a hostile reaction
- Repression
- Many hostile people try to repress their hostility
- Stress & Cardiovascular Reactivity
- Heart & Stress
- Stress & Death
- Causes of death past & present
- Hypertension
- 90% of hypertension is unknown about the cause
- Inflammation
- Reactivity Hypothesis
- Chronic over response to psychological stress
- Time of Recovery is more important that reactance
- Mechanisms
- Lack of recovery leads to heart disease
- Key Studies
- Bowman Gray Medical School studies using cynomolgus monkeys
- Looked at diet and housing conditions
- They were able to show that monkeys develop a hierarchy and they would stress them by mixing them each week
- High fat diet vs social stress
- Both stress and high fat diet both alone will predict high plaque buildup and together it caused the most plaque buildup and heart disease
- Stress & Social Factors
- Social Neuroscience
- Cool area
- House 1988
- Uchino 1996
- Cole 2007
- Genetics underlying loneliness
- higher in loneliness had more inflammatory factor expression
- Gallo 1999
- Looked at hostility
- Social support does not benefit people who are hostile
- Religiosity and Culture
- Effects of religion
- can be good or bad for your health depending on your perception
- Effects of Culture (Donnison & Blood Pleasure)
- Donnison went to kenya and found blood pressure does not have to rise with age
- It is still said here that age is a predictor of blood pressure
- Social Status
- Social gradient
- income and education predict health better than diet
- Cultural gradient
- non western cultures don't value income and education like they do here so you don't see the effects of the social gradient
- Hispanic Paradox
- The idea that recently arrived immigrants are one of the poorest groups in the US but also one of the healthiest. This is a confound to the social gradient.
- Overall
- The quote
- We can change our health through thoughts, emotions, and memory
- Acute stress response
- Sympathetic and Parasympathetic
- Sympathetic: fight or flight energy
- Parasympathetic: rest
- you need to have both of these but they need to be balanced
- HPA axis
- Hypothalamic Puituitary Adrenal
- Stress management (don't need to focus too much on this)
- Stress & Health
- Go through all the power points
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